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(tmp) 2 Zn⋅2 MgCl 2 ⋅2 LiCl: A Chemoselective Base for the Directed Zincation of Sensitive Arenes and Heteroarenes
Author(s) -
Wunderlich Stefan H.,
Knochel Paul
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701984
Subject(s) - reagent , chemistry , zinc , aryl , nitro , base (topology) , medicinal chemistry , organic chemistry , polymer chemistry , alkyl , mathematical analysis , mathematics
Positive zincing : A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF by direct zincation using (tmp) 2 Zn⋅2 MgCl 2 ⋅2 LiCl ( 1 ), an exceptionally active base. Ester and cyano functions as well as aldehydes and nitro groups are tolerated. dba=dibenzylideneacetone, tmp=2,2,6,6‐tetramethylpiperidide.
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