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The Pursuit of Palau'amine
Author(s) -
Köck Matthias,
Grube Achim,
Seiple Ian B.,
Baran Phil S.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701798
Subject(s) - amine gas treating , natural product , biogenesis , skepticism , product (mathematics) , natural (archaeology) , environmental ethics , chemistry , philosophy , geography , stereochemistry , archaeology , epistemology , organic chemistry , biochemistry , mathematics , geometry , gene
Since its discovery in 1993, the marine natural product palau'amine has intrigued natural product chemists. Its exotic molecular architecture and purported bioactivity made it an ideal target for synthesis. However, as the years went by and related marine alkaloids were isolated, a skeptical eye was cast on the structure of palau'amine; recently these suspicions were confirmed and the structure of palau'amine revised. This Minireview gives a careful overview of the structural revision and its ramifications to both its biogenesis and total synthesis.