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One‐Pot Enzymatic Resolution and Separation of sec ‐Alcohols Based on Ionic Acylating Agents
Author(s) -
Lourenço Nuno M. T.,
Afonso Carlos A. M.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701774
Subject(s) - candida antarctica , ionic liquid , kinetic resolution , chemistry , resolution (logic) , acylation , lipase , transesterification , organic chemistry , enantiomer , solvent , extraction (chemistry) , chromatography , catalysis , enzyme , enantioselective synthesis , computer science , artificial intelligence
Going their different ways : A simple, robust, efficient, and reusable system for the one‐pot preparative resolution and separation of sec ‐alcohols is described. The system is based on the combination of sequential enzymatic kinetic resolution (lipase B from Candida Antarctica , CALB) and transesterification in ionic liquids (ILs) with an ionic acylating agent 1 and removal of each enantiomer by extraction with an organic solvent.