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Assignment of the Absolute Configuration of the Marine Pentacyclic Polyether (+)‐Enshuol by Total Synthesis
Author(s) -
Morimoto Yoshiki,
Yata Hiromi,
Nishikawa Yoshihiro
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701737
Subject(s) - absolute configuration , triterpene , total synthesis , stereochemistry , chemistry , absolute (philosophy) , philosophy , epistemology , medicine , alternative medicine , pathology
Finding its true identity : The complete stereostructure of the marine pentacyclic triterpene polyether (+)‐enshuol is shown. Asymmetric total synthesis confirmed the configuration predicted on the basis of NMR spectroscopic data of the previously synthesized natural products aurilol and glabrescol, substructures of which are present in enshuol, and disproved an earlier prediction based on biogenetic considerations.