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Enantioselective Synthesis of Complementary Double‐Helical Molecules that Catalyze Asymmetric Reactions
Author(s) -
Hasegawa Takashi,
Furusho Yoshio,
Katagiri Hiroshi,
Yashima Eiji
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701735
Subject(s) - enantioselective synthesis , ligand (biochemistry) , cyclopropanation , chiral ligand , chemistry , stereochemistry , phosphine , molecule , twist , optically active , helix (gastropod) , chirality (physics) , catalysis , organic chemistry , receptor , physics , biology , biochemistry , geometry , mathematics , nambu–jona lasinio model , ecology , chiral symmetry breaking , quantum mechanics , quark , snail
Two twisted : Optically active double helices were synthesized through a twist‐sense bias induced by a chiral phosphine ligand on one of the complementary metallostrands followed by a ligand‐exchange reaction with an achiral bidentate ligand, which replaces the chiral ligand, to bridge the two strands. Furthermore, the double helices can efficiently catalyze asymmetric cyclopropanation.