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A Two‐Photon Fluorescent Probe for Calcium Waves in Living Tissue
Author(s) -
Kim Hwan Myung,
Kim Bo Ra,
Hong Jin Hee,
Park JinSung,
Lee Kyoung J.,
Cho Bong Rae
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701720
Subject(s) - photobleaching , fluorescence , calcium , fluorescence recovery after photobleaching , photon , two photon excitation microscopy , computer science , chemistry , nanotechnology , physics , optics , materials science , organic chemistry
Intracellular messaging : The novel two‐photon fluorescent probe ACa1 can visualize calcium waves in cells and living tissue for a long period of time and without any mistargeting problems (see picture). The probe is capable of monitoring the calcium waves at a depth of about 150 μm in living tissues for more than 1100 s and with no photobleaching artifacts.