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What is Amphidinolide V? Report on a Likely Conquest
Author(s) -
Fürstner Alois,
Larionov Oleg,
Flügge Susanne
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701640
Subject(s) - chemistry , metathesis , natural product , salt metathesis reaction , conquest , stereochemistry , epoxide , combinatorial chemistry , organic chemistry , catalysis , ancient history , history , polymerization , polymer
The awesome power of metathesis is reflected in the synthesis of the proposed structure of the cytotoxic natural product amphidinolide V, as well as of all other stereomers containing a trans ‐epoxide unit. It can be concluded from the comprehensive data set obtained that the 8 S ,9 R ,10 R ,13 S ‐configured compound 1 most likely represents amphidinolide V, even though a single resonance in the 1 H NMR spectrum deviates from the reported value.