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Photoamplification and Multiple Tag Release in a Linear Peptide‐Based Array of Dithiane Adducts
Author(s) -
Majjigapu Kavitha,
Majjigapu Janaki R. R.,
Kutateladze Andrei G.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701512
Subject(s) - dithiane , adduct , peptide , lysine , chemistry , combinatorial chemistry , domino , photochemistry , stereochemistry , organic chemistry , biochemistry , amino acid , catalysis
Binary encoding and amplification can be achieved in linear polypeptide‐based scaffolds of photoactive dithiane adducts. QA masked sensitizer is tethered to lysine and incorporated in a peptide chain terminated with a sensitizer (see picture). When illuminated, the sensitizer induces fragmentation, thus unmasking more sensitizer and resulting in a linear domino photoamplification effect.