Photoamplification and Multiple Tag Release in a Linear Peptide‐Based Array of Dithiane Adducts | Zendy

Majjigapu Kavitha | Zendy; Majjigapu Janaki R. R. | Zendy; Kutateladze Andrei G. | Zendy

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Photoamplification and Multiple Tag Release in a Linear Peptide‐Based Array of Dithiane Adducts

Author(s) -

Majjigapu Kavitha,

Majjigapu Janaki R. R.,

Kutateladze Andrei G.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200701512

Subject(s) - dithiane , adduct , peptide , lysine , chemistry , combinatorial chemistry , domino , photochemistry , stereochemistry , organic chemistry , biochemistry , amino acid , catalysis

Binary encoding and amplification can be achieved in linear polypeptide‐based scaffolds of photoactive dithiane adducts. QA masked sensitizer is tethered to lysine and incorporated in a peptide chain terminated with a sensitizer (see picture). When illuminated, the sensitizer induces fragmentation, thus unmasking more sensitizer and resulting in a linear domino photoamplification effect.

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