Premium
Stereoselective Synthesis of α‐Allenols by Rhodium‐Catalyzed Reaction of Alkynyl Oxiranes with Arylboronic Acids
Author(s) -
Miura Tomoya,
Shimada Masahiko,
Ku SungYu,
Tamai Tomohiro,
Murakami Masahiro
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701505
Subject(s) - rhodium , stereoselectivity , catalysis , chemistry , reactivity (psychology) , oxygen atom , ring (chemistry) , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule , medicine , alternative medicine , pathology
Better than Cu, Pd, and Fe catalysts : The rhodium‐catalyzed reaction of alkynyl oxiranes with arylboronic acids provides syn ‐configured α‐allenols with excellent diastereoselectivity. Precoordination of the oxygen atom of the oxirane ring to rhodium is assumed to contribute to the high stereoselectivity as well as high reactivity.