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Catalytic Enantioselective Tautomerization of Isolated Enols
Author(s) -
Fehr Charles
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701428
Subject(s) - enantioselective synthesis , tautomer , protonation , catalysis , chemistry , enol , organic chemistry , stereochemistry , ion
Smells like roses : The catalytic enantioselective ketonization of two isolated enols was successful and made possible the discussion of the important mechanistic implications of these findings. The indirect enolate protonation occurs via enols and higher‐order mixed aggregates (see scheme). The reaction was used to synthesize the rose‐smelling fragrance compound ( S )‐α‐damascone.