Protein Kinase Assay on Peptide‐Conjugated Gold Nanoparticles by Using Secondary‐Ion Mass Spectrometric Imaging | Zendy

Kim YoungPil | Zendy; Oh Eunkeu | Zendy; Oh YoungHee | Zendy; Moon Dae Won | Zendy; Lee Tae Geol | Zendy; Kim HakSung | Zendy

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Protein Kinase Assay on Peptide‐Conjugated Gold Nanoparticles by Using Secondary‐Ion Mass Spectrometric Imaging

Author(s) -

Kim YoungPil,

Oh Eunkeu,

Oh YoungHee,

Moon Dae Won,

Lee Tae Geol,

Kim HakSung

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200701418

Subject(s) - peptide , conjugated system , colloidal gold , chemistry , mass spectrometry , nanoparticle , protein kinase a , chromatography , kinase , biochemistry , materials science , nanotechnology , organic chemistry , polymer

Spot the mass of peptides : A label‐free protein kinase assay that uses secondary‐ion mass spectrometric imaging has been demonstrated with peptide‐conjugated gold nanoparticles (AuNPs). With detection of the mass change of peptide substrates in a kinase reaction, AuNP‐enhanced peptide signals enabled the assaying of both the protein kinase and its inhibition by chemical imaging of peptide substrates on a surface (see picture).

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