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Signal‐Amplifying Resonance Energy Transfer: A Dynamic Multichromophore Array for Allosteric Switching
Author(s) -
Riddle Justin A.,
Jiang Xuan,
Huffman John,
Lee Dongwhan
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701410
Subject(s) - signal (programming language) , allosteric regulation , folding (dsp implementation) , förster resonance energy transfer , sigmoid function , acceptor , resonance (particle physics) , energy (signal processing) , computer science , turn (biochemistry) , transfer (computing) , energy transfer , chemistry , physics , biological system , nuclear magnetic resonance , artificial intelligence , chemical physics , electrical engineering , artificial neural network , biology , optics , engineering , condensed matter physics , atomic physics , enzyme , quantum mechanics , fluorescence , programming language , parallel computing
Cooperative structural folding and unfolding of a dynamic multichromophore array provides an unusual signal amplification as part of a resonance energy transfer from the central donor unit to peripheral acceptor ensembles. The stepwise addition and removal of chemical input signals resulted in reversible, sigmoidal response curves in both the turn‐on and turn‐off scans (see picture).