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Polymorphism in Benzamide: Solving a 175‐Year‐Old Riddle
Author(s) -
Thun Jürgen,
Seyfarth Lena,
Senker Jürgen,
Dinnebier Robert E.,
Breu Josef
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701383
Subject(s) - benzamide , metastability , polymorphism (computer science) , crystallization , computer science , chemistry , stereochemistry , organic chemistry , biochemistry , gene , allele
A third form of benzamide has been characterized 175 years after the first report of polymorphism in benzamide; the metastable silky needlelike form first described by Wöhler and Liebig was “hidden” for so long owing to the similarities between the metrics of its unit cell and those of the stable form I (the H‐bonding motif is depicted). Selective crystallization techniques taking advantage of modern online sensors were crucial in this work.