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Reversible Surface Switching of Nanogel Triggered by External Stimuli
Author(s) -
Shen Xiaochen,
Zhang Leyang,
Jiang Xiqun,
Hu Yong,
Guo Jian
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701368
Subject(s) - nanogel , ethylenediaminetetraacetic acid , materials science , chemical engineering , particle (ecology) , surface charge , biocompatible material , nanotechnology , chemistry , biomedical engineering , drug delivery , medicine , metallurgy , oceanography , chelation , geology , engineering
Inside out and back again : A novel nanogel composed of two biocompatible components, namely chitosan and ethylenediaminetetraacetic acid, is presented and shows novel surface switching of both composition and charge in response to pH changes in the medium (see picture). The pH‐dependent surface switch of this nanogel is fully reversible and the particle integrity is maintained in the entire pH range owing to the gel nature of the system.