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Catalytic Enantioselective Reduction of β,β‐Disubstituted Vinyl Phenyl Sulfones by Using Bisphosphine Monoxide Ligands
Author(s) -
Desrosiers JeanNicolas,
Charette André B.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701367
Subject(s) - hydrosilylation , phosphine , enantioselective synthesis , chemistry , monoxide , ligand (biochemistry) , carbon monoxide , enantiomer , catalysis , alkyl , combinatorial chemistry , organic chemistry , receptor , biochemistry
Synthesis of chiral sulfones : A copper–phosphine complex efficiently provided optically active alkyl phenyl sulfones by hydrosilylation at room temperature. The reduction of β,β‐disubstituted vinyl sulfones in the presence of the Me‐DuPhos monoxide ligand lead to excellent enantiomeric excesses and high yields (see scheme). The prepared chiral sulfones were desulfonylated and subjected to Julia olefination conditions.