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A Concise Synthesis of Enantioenriched Fluorinated Carbocycles
Author(s) -
Lam Yuhong,
Bobbio Carla,
Cooper Ian R.,
Gouverneur Véronique
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701365
Subject(s) - stereocenter , cycloaddition , combinatorial chemistry , process (computing) , chemistry , stereochemistry , computer science , organic chemistry , catalysis , enantioselective synthesis , programming language
A “reverse” cycloaddition–fluorination strategy has been validated to access enantioenriched fluorinated compounds featuring up to five stereogenic centers, one of which is fluorinated. This highly convergent process features a mild and high‐yielding fluorination, for which the sense and level of stereocontrol have been probed.