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Regio‐ and Stereoselective Synthesis of Enamides and Dienamides by Ruthenium‐Catalyzed Co‐Oligomerization of N ‐Vinylamides with Alkenes or Alkynes
Author(s) -
Tsujita Hiroshi,
Ura Yasuyuki,
Matsuki Shingo,
Wada Kenji,
Mitsudo Takeaki,
Kondo Teruyuki
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701356
Subject(s) - ruthenium , catalysis , ethylene , chemistry , stereoselectivity , acrylate , methyl acrylate , combinatorial chemistry , medicinal chemistry , organic chemistry , copolymer , polymer
The zero‐valent ruthenium complex (η 6 ‐1,3,5‐cyclooctatriene)bis(η 2 ‐dimethyl fumarate)ruthenium effectively catalyzes the highly selective codimerization of N ‐vinylamides with alkenes or alkynes and was successfully applied in the cotrimerization of N ‐vinylamides with ethyl acrylate and ethylene (see scheme). These reactions offer a rapid and atom‐economical synthesis of biologically and synthetically important enamides and dienamides.