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Guanidine‐Containing Molecular Transporters: Sorbitol‐Based Transporters Show High Intracellular Selectivity toward Mitochondria
Author(s) -
Maiti Kaustabh K.,
Lee Woo Sirl,
Takeuchi Toshihide,
Watkins Catherine,
Fretz Marjan,
Kim DongChan,
Futaki Shiroh,
Jones Arwyn,
Kim KyongTai,
Chung SungKee
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701346
Subject(s) - transporter , intracellular , guanidine , mitochondrion , biochemistry , sorbitol , chemistry , microbiology and biotechnology , biophysics , biology , gene
Special delivery : Transporters constructed on a sorbitol scaffold with eight guanidine residues show significant translocation across the cell membrane and the blood–brain barrier and high affinities toward mitochondria in HeLa and KG1a leukemia cells. The picture shows colocalisation of one such transporter ( T ) with MitoTracker red in KG1a cells (scale bars: 10 μm).