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Solid‐Phase Synthesis of Epigallocatechin Gallate Derivatives
Author(s) -
Tanaka Hiroshi,
Miyoshi Haruko,
Chuang YuCheng,
Ando Yoshio,
Takahashi Takashi
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701276
Subject(s) - trifluoroacetic acid , gallate , chemistry , ketone , epigallocatechin gallate , polystyrene , solid phase synthesis , phase (matter) , organic chemistry , combinatorial chemistry , polyphenol , nuclear chemistry , antioxidant , peptide , biochemistry , polymer
Without a trace… The natural product epigallocatechin gallate (see scheme, right) and a library of derivatives were synthesized on a solid phase. Reductive etherification upon the release of the α‐acyloxy ketone intermediate from the resin provided the desired epicatechin derivatives. Bn=benzyl, PS=polystyrene, TFA=trifluoroacetic acid.