Solid‐Phase Synthesis of Epigallocatechin Gallate Derivatives | Zendy

Tanaka Hiroshi | Zendy; Miyoshi Haruko | Zendy; Chuang YuCheng | Zendy; Ando Yoshio | Zendy; Takahashi Takashi | Zendy

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Solid‐Phase Synthesis of Epigallocatechin Gallate Derivatives

Author(s) -

Tanaka Hiroshi,

Miyoshi Haruko,

Chuang YuCheng,

Ando Yoshio,

Takahashi Takashi

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200701276

Subject(s) - trifluoroacetic acid , gallate , chemistry , ketone , epigallocatechin gallate , polystyrene , solid phase synthesis , phase (matter) , organic chemistry , combinatorial chemistry , polyphenol , nuclear chemistry , antioxidant , peptide , biochemistry , polymer

Without a trace… The natural product epigallocatechin gallate (see scheme, right) and a library of derivatives were synthesized on a solid phase. Reductive etherification upon the release of the α‐acyloxy ketone intermediate from the resin provided the desired epicatechin derivatives. Bn=benzyl, PS=polystyrene, TFA=trifluoroacetic acid.

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