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The Discriminatory Power of Differential Receptor Arrays Is Improved by Prescreening—A Demonstration in the Analysis of Tachykinins and Similar Peptides
Author(s) -
Wright Aaron T.,
Edwards Nicola Y.,
Anslyn Eric V.,
McDevitt John T.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701236
Subject(s) - substance p , neurokinin a , receptor , chemistry , tachykinin receptor , neurotransmitter , neuropeptide , biochemistry
Patterning pain : Six strong‐binding receptors for the decapeptide tachykinin neurotransmitter α‐neurokinin were identified by screening a solid‐supported library. Solution‐phase studies with these six receptors metalated with three different metal salts in a 96‐well plate array followed by principal component analysis showed the array's ability to recognize and discriminate substance P and α‐neurokinin, as well as three similar peptides.