The Discriminatory Power of Differential Receptor Arrays Is Improved by Prescreening—A Demonstration in the Analysis of Tachykinins and Similar Peptides | Zendy

Wright Aaron T. | Zendy; Edwards Nicola Y. | Zendy; Anslyn Eric V. | Zendy; McDevitt John T. | Zendy

Premium

The Discriminatory Power of Differential Receptor Arrays Is Improved by Prescreening—A Demonstration in the Analysis of Tachykinins and Similar Peptides

Author(s) -

Wright Aaron T.,

Edwards Nicola Y.,

Anslyn Eric V.,

McDevitt John T.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200701236

Subject(s) - substance p , neurokinin a , receptor , chemistry , tachykinin receptor , neurotransmitter , neuropeptide , biochemistry

Patterning pain : Six strong‐binding receptors for the decapeptide tachykinin neurotransmitter α‐neurokinin were identified by screening a solid‐supported library. Solution‐phase studies with these six receptors metalated with three different metal salts in a 96‐well plate array followed by principal component analysis showed the array's ability to recognize and discriminate substance P and α‐neurokinin, as well as three similar peptides.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research