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Asymmetric Organocatalytic α‐Arylation of Aldehydes
Author(s) -
Alemán José,
Cabrera Silvia,
Maerten Eddy,
Overgaard Jacob,
Jørgensen Karl Anker
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701207
Subject(s) - enantioselective synthesis , chemistry , trimethylsilyl , status quo , solvent , optically active , scheme (mathematics) , organic chemistry , catalysis , combinatorial chemistry , mathematics , political science , law , mathematical analysis
Quinone pro quo : The organocatalytic enantioselective α‐arylation of aldehydes using quinones as the aromatic partner was carried out. The reaction proceeds well using H 2 O or EtOH/H 2 O mixtures as solvent. The corresponding optically active α‐arylated aldehydes are obtained in high yields and with excellent enantioselectivities (see scheme; TMS: trimethylsilyl).