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Highly Enantioselective Aryl Additions of [AlAr 3 (thf)] to Ketones Catalyzed by a Titanium(IV) Catalyst of ( S )‐Binol
Author(s) -
Chen ChienAn,
Wu KuoHui,
Gau HanMou
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701201
Subject(s) - enantioselective synthesis , aryl , catalysis , titanium , chemistry , ligand (biochemistry) , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , alkyl , receptor
Chiral transfer : Novel asymmetric aryl transfers from [AlAr 3 (thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with ( S )‐binol as the chiral ligand. The reaction affords tertiary alcohols with enantioselectivities up to 97 % ee (see scheme). Binol=2,2′‐dihydroxy‐1,1′‐binaphthyl.