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Probing Local Structural Events in β‐Hairpin Unfolding with Transient Nonlinear Infrared Spectroscopy
Author(s) -
Smith Adam W.,
Tokmakoff Andrei
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701172
Subject(s) - nonlinear system , folding (dsp implementation) , transient (computer programming) , jump , infrared , spectroscopy , infrared spectroscopy , chemical physics , content (measure theory) , temperature jump , physics , chemistry , crystallography , computer science , optics , mathematics , engineering , quantum mechanics , electrical engineering , mathematical analysis , operating system
Fast dynamics and kinky turns : The designed peptide PG12 forms a β‐hairpin stabilized by a D ‐Pro enhanced type‐II′ β turn. Through a combination of 13 C′ isotope labels and temperature‐jump nonlinear infrared spectroscopy local folding events were observed on a submicrosecond timescale, in which the turn region remains structured during the temperature jump, and midstrand region opens up on a 130‐ns timescale.