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Cu I ‐Catalyzed Conjugate Addition of Ethyl Propiolate
Author(s) -
Fujimori Shinji,
Carreira Erick M.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701098
Subject(s) - conjugate , adduct , chemistry , catalysis , stereoselectivity , copper , addition reaction , combinatorial chemistry , organic chemistry , mathematical analysis , mathematics
More functionality possible : The conjugate addition of ethyl propiolate to Meldrum's acid derived acceptors is described. These reactions proceed under mild conditions employing substoichiometric amounts of a copper(I) species generated in situ. When chiral acceptors are employed as substrates, the additions are stereoselective and provide the addition adduct with high diastereoselectivity.