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Approaching the Megadalton: NMR Spectroscopy of Protein Complexes
Author(s) -
Luy Burkhard
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701093
Subject(s) - nuclear magnetic resonance spectroscopy , spectroscopy , chemistry , crystallography , materials science , nuclear magnetic resonance , physics , quantum mechanics
Bigger and bigger : A decade ago the size limit for biomolecular NMR spectroscopy was thought to be on the order of 30 kDa. Now quantitative NMR‐relaxation studies have been reported for a 670‐kDa complex (see structure; red: Me groups with slow dynamics, yellow: Me groups at highly flexible N termini). The key developments that led to the remarkable work are presented.