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Fabrication of Cellular Multilayers with Nanometer‐Sized Extracellular Matrix Films
Author(s) -
Matsusaki Michiya,
Kadowaki Koji,
Nakahara Yoshio,
Akashi Mitsuru
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701089
Subject(s) - extracellular matrix , fabrication , fibronectin , nanometre , bilayer , materials science , nanotechnology , layer (electronics) , gelatin , matrix (chemical analysis) , chemistry , membrane , composite material , medicine , biochemistry , alternative medicine , pathology
Layer it on : Cellular multilayers were fabricated by preparing nanometer‐sized extracellular matrix (ECM) films (6‐nm thick) with fibronectin (FN) and gelatin on the surface of each cell layer. The four‐layer cellular architecture was well organized and self‐standing. Xenogenic human bilayer architectures similar to blood vessels were prepared by fabrication of the nanofilms on cell surfaces.