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Site‐Isolated Base‐ and Acid‐Mediated Michael‐Initiated Cyclization Cascades
Author(s) -
Pilling Adam W.,
Boehmer Jutta,
Dixon Darren J.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701079
Subject(s) - base (topology) , michael reaction , chemistry , biochemistry , mathematics , catalysis , mathematical analysis
One thing leads to another : Site‐isolated base and acid catalysts have been exploited in Michael addition, N ‐acyl iminium ion cyclization cascades with amide pronucleophiles and α,β‐unsaturated carbonyl compounds. The reaction sequence has broad scope, uses commercially available catalysts, is atom efficient, and can be scaled by way of a flow‐reactor setup.