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Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad‐Spectrum Antibiotic Activity
Author(s) -
Jayasuriya Hiranthi,
Herath Kithsiri B.,
Zhang Chaowei,
Zink Deborah L.,
Basilio Angela,
Genilloud Olga,
Diez Maria Teresa,
Vicente Francisca,
Gonzalez Ignacio,
Salazar Oscar,
Pelaez Fernando,
Cummings Richard,
Ha Sookhee,
Wang Jun,
Singh Sheo B.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701058
Subject(s) - broad spectrum , antibiotics , isolation (microbiology) , dual (grammatical number) , mode of action , chemistry , computational biology , biology , biochemistry , combinatorial chemistry , microbiology and biotechnology , philosophy , linguistics
Two birds with one stone : Platencin ( 1 ) is a novel and potent broad‐spectrum Gram‐positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF, platencin exerts its activity by a novel mode of action by dual inhibition of FabH and FabF.