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Immuno‐Polymeric Nanoparticles by Diels–Alder Chemistry
Author(s) -
Shi Meng,
Wosnick Jordan H.,
Ho Karyn,
Keating Armand,
Shoichet Molly S.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701032
Subject(s) - diels–alder reaction , alder , nanoparticle , chemistry , polymer science , nanotechnology , organic chemistry , materials science , catalysis , biology , ecology
Hitting the target : Self‐assembled polymeric nanoparticles from an amphiphilic copolymer were prepared with furan groups on the outer polyethylene glycol corona that were accessible for Diels–Alder reactions with maleimide‐functionalized antibodies for the preparation of immuno‐nanoparticles (see picture). The simple and clean coupling methodology allows facile modification of nanoparticles for use in targeted delivery to cancer cells.