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Organocatalytic Highly Enantioselective α‐Arylation of β‐Ketoesters
Author(s) -
Alemán José,
Richter Bo,
Jørgensen Karl Anker
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200701009
Subject(s) - enantioselective synthesis , organocatalysis , chemistry , combinatorial chemistry , stereochemistry , catalysis , organic chemistry
Quintessential quinones : The reaction of β‐ketoesters with quinones provides a strategy to perform α‐arylations, particularly when the α‐aryl ring contains electron‐donating groups. The reaction can be carried out enantioselectively by using cinchona alkaloids as organocatalysts and allows the synthesis of complicated polycyclic and spiro chiral compounds.