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Enantioselective Organocatalytic Hydrophosphination of α,β‐Unsaturated Aldehydes
Author(s) -
Ibrahem Ismail,
Rios Ramon,
Vesely Jan,
Hammar Peter,
Eriksson Lars,
Himo Fahmi,
Córdova Armando
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700916
Subject(s) - enantioselective synthesis , phosphine , phosphine oxide , simple (philosophy) , chemistry , transformation (genetics) , organic chemistry , optically active , combinatorial chemistry , computer science , catalysis , philosophy , biochemistry , epistemology , gene
Keeping it simple : Optically active phosphine derivatives can be obtained in high yields and in up to 99 % ee by using simple chiral amines to catalyze the hydrophosphination of α,β‐unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo‐ and enantioselective transformation was exemplified by the one‐pot asymmetric synthesis of β‐phosphine oxide acids.