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Rhodium‐Catalyzed Aryl Transfer from Trisubstituted Aryl Methanols to α,β‐Unsaturated Carbonyl Compounds
Author(s) -
Nishimura Takahiro,
Katoh Taisuke,
Hayashi Tamio
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700902
Subject(s) - rhodium , aryl , reagent , chemistry , alkoxide , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl
A process of elimination : The rhodium‐catalyzed arylation of α,β‐unsaturated carbonyl compounds with 9‐aryl‐10‐benzyl‐9,10‐dihydroacridin‐9‐ols 1 as arylating reagents proceeds efficiently via β‐aryl elimination of the rhodium alkoxide intermediates, to give the 1,4‐addition products in high yields (see scheme; Bn=benzyl, cod=cycloocta‐1,5‐diene).