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Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl 2 ‐Catalyzed Cycloisomerization Reaction
Author(s) -
Fürstner Alois,
Heilmann Eike K.,
Davies Paul W.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700895
Subject(s) - cycloisomerization , natural product , chemistry , catalysis , total synthesis , alkyne , derivative (finance) , antibiotics , vancomycin , combinatorial chemistry , microbiology and biotechnology , stereochemistry , bacteria , biology , organic chemistry , staphylococcus aureus , business , genetics , finance
Fighting back : A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin‐resistant Staphyllococcus aureus strains and vancomycin‐resistant enterococci, has been developed. The key step in the synthesis is a PtCl 2 ‐catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).