Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl 2 ‐Catalyzed Cycloisomerization Reaction | Zendy

Fürstner Alois | Zendy; Heilmann Eike K. | Zendy; Davies Paul W. | Zendy

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Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl 2 ‐Catalyzed Cycloisomerization Reaction

Author(s) -

Fürstner Alois,

Heilmann Eike K.,

Davies Paul W.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700895

Subject(s) - cycloisomerization , natural product , chemistry , catalysis , total synthesis , alkyne , derivative (finance) , antibiotics , vancomycin , combinatorial chemistry , microbiology and biotechnology , stereochemistry , bacteria , biology , organic chemistry , staphylococcus aureus , business , genetics , finance

Fighting back : A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin‐resistant Staphyllococcus aureus strains and vancomycin‐resistant enterococci, has been developed. The key step in the synthesis is a PtCl 2 ‐catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).

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