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Peptide Fibrillization
Author(s) -
Hamley Ian W.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700861
Subject(s) - peptide , amyloid fibril , fibril , self healing hydrogels , chemistry , nanotechnology , self assembly , amyloid (mycology) , amphiphile , biophysics , materials science , biochemistry , polymer , copolymer , amyloid β , polymer chemistry , organic chemistry , biology , medicine , inorganic chemistry , disease , pathology
Abstract The fibrillization of peptides is relevant to many diseases based on the deposition of amyloids. The formation of fibrils is being intensively studied, especially in terms of nanotechnology applications, where fibrillar peptide hydrogels are used for cell scaffolds, as supports for functional and responsive biomaterials, biosensors, and nanowires. This Review is concerned with fundamental aspects of the self‐assembly of peptides into fibrils, and discusses both natural amyloid‐forming peptides and synthetic materials, including peptide fragments, copolymers, and amphiphiles.