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Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents
Author(s) -
Weng Xiaocheng,
Ren Lige,
Weng Liwei,
Huang Jing,
Zhu Shugao,
Zhou Xiang,
Weng Linhong
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700844
Subject(s) - sodium periodate , dna , biphenyl , chemistry , derivative (finance) , periodate , duplex (building) , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , business , finance
Checking the traps : When a phenyl selenide compound such as 1 was oxidized with sodium periodate or irradiated, an ortho ‐quinone methide intermediate formed and reacted with a DNA duplex by cross‐linking. In the crystal structure of a derivative of 1 the biphenyl unit is twisted, and this might explain how 1 can interact effectively with the DNA backbone.