Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents | Zendy

Weng Xiaocheng | Zendy; Ren Lige | Zendy; Weng Liwei | Zendy; Huang Jing | Zendy; Zhu Shugao | Zendy; Zhou Xiang | Zendy; Weng Linhong | Zendy

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Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents

Author(s) -

Weng Xiaocheng,

Ren Lige,

Weng Liwei,

Huang Jing,

Zhu Shugao,

Zhou Xiang,

Weng Linhong

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700844

Subject(s) - sodium periodate , dna , biphenyl , chemistry , derivative (finance) , periodate , duplex (building) , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , business , finance

Checking the traps : When a phenyl selenide compound such as 1 was oxidized with sodium periodate or irradiated, an ortho ‐quinone methide intermediate formed and reacted with a DNA duplex by cross‐linking. In the crystal structure of a derivative of 1 the biphenyl unit is twisted, and this might explain how 1 can interact effectively with the DNA backbone.

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