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Tetraarylphosphonium Salts as Soluble Supports for the Synthesis of Small Molecules
Author(s) -
Stazi Federica,
Marcoux David,
Poupon JeanChristophe,
Latassa Daniel,
Charette André B.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700833
Subject(s) - phosphonium , combinatorial chemistry , chemistry , solubility , piperidine , variety (cybernetics) , small molecule , solid phase synthesis , phase (matter) , peptide synthesis , molecule , organic chemistry , computer science , peptide , biochemistry , artificial intelligence
Support groups : Phosphonium salts can be used as solubility‐control groups (SCGs) in small‐molecule and peptide synthesis (see scheme). The concept, which is a hybrid approach between solution‐ and solid‐phase syntheses, is illustrated by the preparation of 2‐substituted piperidine derivatives and a variety of small peptides with high yields and purities. In some cases, recycling of the support is possible.