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A General Approach to Chemo‐ and Regioselective Cyclotrimerization Reactions
Author(s) -
Young Douglas D.,
Deiters Alexander
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700802
Subject(s) - regioselectivity , nitrile , microwave irradiation , pyridine , yield (engineering) , chemistry , microwave , combinatorial chemistry , cobalt , catalysis , organic chemistry , polymer chemistry , materials science , computer science , telecommunications , metallurgy
Microwave‐ready heterocycles : Cobalt‐catalyzed [2+2+2] cyclotrimerization of nitrile derivatives with diynes anchored to a solid support under microwave irradiation provides a universal approach to pyridine, pyridone, and iminopyridine products. The reaction is completely chemo‐ and regioselective, and the products are obtained in excellent yield and high purity.