Protein‐Phosphorylation‐Responsive Polymeric Nanoparticles for Imaging Protein Kinase Activities in Single Living Cells | Zendy

Kim JongHo | Zendy; Lee Seulki | Zendy; Park Kyeongsoon | Zendy; Nam Hae Yun | Zendy; Jang Soon Young | Zendy; Youn Inchan | Zendy; Kim Kwangmeyung | Zendy; Jeon Hyesung | Zendy; Park RangWoon | Zendy; Kim InSan | Zendy; Choi Kuiwon | Zendy; Kwon Ick Chan | Zendy

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Protein‐Phosphorylation‐Responsive Polymeric Nanoparticles for Imaging Protein Kinase Activities in Single Living Cells

Author(s) -

Kim JongHo,

Lee Seulki,

Park Kyeongsoon,

Nam Hae Yun,

Jang Soon Young,

Youn Inchan,

Kim Kwangmeyung,

Jeon Hyesung,

Park RangWoon,

Kim InSan,

Choi Kuiwon,

Kwon Ick Chan

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700767

Subject(s) - protein kinase a , förster resonance energy transfer , protein phosphorylation , kinase , biochemistry , chemistry , cyclin dependent kinase 2 , map2k7 , protein kinase inhibitor , fluorophore , phosphorylation , microbiology and biotechnology , biology , fluorescence , physics , quantum mechanics

Take your PIC : Cell‐permeable and biocompatible polyion‐induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near‐infrared fluorophore and a protein‐kinase‐specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP=adenosine triphosphate, ADP=adenosine diphosphate.

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