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A Long Research Story Culminates in the First Total Synthesis of Moenomycin A
Author(s) -
Welzel Peter
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700765
Subject(s) - total synthesis , stereochemistry , chemistry
The highly active inhibitor of the “forgotten” transglycosylases, moenomycin A, succumbed to total synthesis. The pentasaccharide backbone was constructed employing sulfoxides as glycosyl donors. The recent moenomycin results should establish it as a promising lead structure for new antiinfectives.