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Stereoselective Syntheses and Reactions of Stannylated Peptides
Author(s) -
Deska Jan,
Kazmaier Uli
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700759
Subject(s) - stereoselectivity , stille reaction , chemistry , tin , coupling reaction , iodine , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
In one fell swoop: Stannylated allyl carbonates allow the highly stereoselective synthesis of metalated peptides, which can be further modified by Stille coupling. Tin–iodine exchange generates iodinated peptides which also can be used for CC coupling reactions. Therefore, only one stereoselective reaction is necessary to generate a wide range of different peptides in stereochemically pure form.