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DNA Binding and Catalytic Properties of Positively Charged Corroles
Author(s) -
Gershman Zoya,
Goldberg Israel,
Gross Zeev
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700757
Subject(s) - corrole , peroxynitrite , porphyrin , chemistry , dna , catalysis , photochemistry , manganese , combinatorial chemistry , biochemistry , organic chemistry , enzyme , superoxide
DNA likes corroles and peroxynitrite doesn't: The water‐soluble manganese corrole (crystal structure shown) is a much better catalyst than the analogous porphyrin for decomposition of peroxynitrite (HOONO). The interactions of the two complexes with DNA are also significantly different. These findings suggest that positively charged corroles may be useful for therapeutic approaches.