Organocatalytic Asymmetric Hydrophosphination of α,β‐Unsaturated Aldehydes

Getting round the (periodic) table : A highly chemo‐ and enantioselective conjugate addition of diphenylphosphine to α,β‐unsaturated aldehydes in the presence of a chiral secondary amine C provides a direct route to chiral β‐phosphino aldehyde intermediates (see scheme, TMS=trimethylsilyl). The synthetic utility of the strategy was exemplified in a rapid one‐pot (two‐step) synthesis of highly enantioenriched 3‐aminophosphines.