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Iron‐Catalyzed Alkylations of Aromatic Grignard Reagents
Author(s) -
Cahiez Gérard,
Habiak Vanessa,
Duplais Christophe,
Moyeux Alban
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700742
Subject(s) - reagent , catalysis , aryl , chemistry , tetramethylethylenediamine , alkyl , combinatorial chemistry , grignard reagent , organic chemistry , medicinal chemistry
Any old iron : Two efficient iron‐catalyzed cross‐coupling reactions between aryl Grignard reagents and alkyl bromides were developed that are suitable for large‐scale applications. The first procedure uses iron acetylacetonate and involves a cooperative effect between the two ligands N , N , N ′, N ′‐tetramethylethylenediamine (TMEDA) and hexamethylenetetraamine (HMTA), while the second procedure uses [(FeCl 3 ) 2 (tmeda) 3 ] as catalyst.
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