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Formation of a Chiral Center and Pyrimidal Inversion at the Single‐Molecule Level
Author(s) -
Shin SeongHo,
Steffensen Mackay B.,
Claridge Tim D. W.,
Bayley Hagan
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700736
Subject(s) - nanoreactor , inversion (geology) , molecule , center (category theory) , covalent bond , chemistry , computational chemistry , combinatorial chemistry , stereochemistry , computer science , nanotechnology , crystallography , materials science , organic chemistry , biology , catalysis , paleontology , structural basin
One‐at‐a‐time stereochemistry : AsS bond‐making and bond‐breaking reactions are important in pharmacology, toxicology, and cell biology. The aqueous covalent chemistry of individual As III molecules can be monitored inside a protein nanoreactor. The approach is used to follow the creation of a chiral center at As III , through the formation of a short‐lived AsS bond, and to monitor inversion at that center (see picture).