Formation of a Chiral Center and Pyrimidal Inversion at the Single‐Molecule Level | Zendy

Shin SeongHo | Zendy; Steffensen Mackay B. | Zendy; Claridge Tim D. W. | Zendy; Bayley Hagan | Zendy

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Formation of a Chiral Center and Pyrimidal Inversion at the Single‐Molecule Level

Author(s) -

Shin SeongHo,

Steffensen Mackay B.,

Claridge Tim D. W.,

Bayley Hagan

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700736

Subject(s) - nanoreactor , inversion (geology) , molecule , center (category theory) , covalent bond , chemistry , computational chemistry , combinatorial chemistry , stereochemistry , computer science , nanotechnology , crystallography , materials science , organic chemistry , biology , catalysis , paleontology , structural basin

One‐at‐a‐time stereochemistry : AsS bond‐making and bond‐breaking reactions are important in pharmacology, toxicology, and cell biology. The aqueous covalent chemistry of individual As III molecules can be monitored inside a protein nanoreactor. The approach is used to follow the creation of a chiral center at As III , through the formation of a short‐lived AsS bond, and to monitor inversion at that center (see picture).

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