Specific Fluorescent Probe for 8‐Oxoguanosine | Zendy

Nakagawa Osamu | Zendy; Ono Sayaka | Zendy; Li Zhichun | Zendy; Tsujimoto Akira | Zendy; Sasaki Shigeki | Zendy

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Specific Fluorescent Probe for 8‐Oxoguanosine

Author(s) -

Nakagawa Osamu,

Ono Sayaka,

Li Zhichun,

Tsujimoto Akira,

Sasaki Shigeki

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700671

Subject(s) - fluorescence , titration , clamp , chemistry , aqueous medium , solubilization , biophysics , computer science , aqueous solution , analytical chemistry (journal) , combinatorial chemistry , chromatography , biochemistry , physics , biology , optics , computer graphics (images) , clamping

Marking mutations : Complete discrimination of 8‐oxoguanosine (8‐oxoG) from other nucleosides has been achieved with a new fluorescent probe, named “8‐oxoG‐clamp” (see picture). The complex structure between 8‐oxoG‐clamp and 8‐oxoG was confirmed by 1 H NMR titration and 2D NMR measurements. A preliminary investigation with use of a detergent for solubilization indicates that 8‐oxoG‐clamp may be applicable in aqueous media.

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