A Formally Zwitterionic Ruthenium Catalyst Precursor for the Transfer Hydrogenation of Ketones that Does Not Feature an Ancillary Ligand NH Functionality | Zendy

Lundgren Rylan J. | Zendy; Rankin Matthew A. | Zendy; McDonald Robert | Zendy; Schatte Gabriele | Zendy; Stradiotto Mark | Zendy

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A Formally Zwitterionic Ruthenium Catalyst Precursor for the Transfer Hydrogenation of Ketones that Does Not Feature an Ancillary Ligand NH Functionality

Author(s) -

Lundgren Rylan J.,

Rankin Matthew A.,

McDonald Robert,

Schatte Gabriele,

Stradiotto Mark

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200700345

Subject(s) - transfer hydrogenation , ruthenium , ligand (biochemistry) , aryl , catalysis , alkyl , transfer (computing) , chemistry , combinatorial chemistry , range (aeronautics) , computer science , medicinal chemistry , organic chemistry , materials science , operating system , biochemistry , receptor , composite material

Fast and furious : Even without the assistance of an NH donor ligand, the Ru complex shown in the scheme is a remarkably active precatalyst for the transfer hydrogenation of ketones in basic i PrOH (R,R′=alkyl or aryl), providing near‐quantitative yields within minutes and exhibiting consistently high turnover frequencies (10 4 to 10 5 h −1 ) for a diverse range of substrates.

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