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A Formally Zwitterionic Ruthenium Catalyst Precursor for the Transfer Hydrogenation of Ketones that Does Not Feature an Ancillary Ligand NH Functionality
Author(s) -
Lundgren Rylan J.,
Rankin Matthew A.,
McDonald Robert,
Schatte Gabriele,
Stradiotto Mark
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700345
Subject(s) - transfer hydrogenation , ruthenium , ligand (biochemistry) , aryl , catalysis , alkyl , transfer (computing) , chemistry , combinatorial chemistry , range (aeronautics) , computer science , medicinal chemistry , organic chemistry , materials science , operating system , biochemistry , receptor , composite material
Fast and furious : Even without the assistance of an NH donor ligand, the Ru complex shown in the scheme is a remarkably active precatalyst for the transfer hydrogenation of ketones in basic i PrOH (R,R′=alkyl or aryl), providing near‐quantitative yields within minutes and exhibiting consistently high turnover frequencies (10 4 to 10 5 h −1 ) for a diverse range of substrates.