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Synthesis and Stereochemical Assignment of FR252921, a Promising Immunosuppressant
Author(s) -
Falck J. Russell,
He Anyu,
Fukui Hiroki,
Tsutsui Hideyuki,
Radha Akella
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700321
Subject(s) - diastereomer , chemistry , scheme (mathematics) , key (lock) , lactone , combinatorial chemistry , natural compound , computer science , stereochemistry , biochemical engineering , mathematics , engineering , mathematical analysis , computer security
Synthetic detective work : FR252921, an unusual 19‐membered lactone–dilactam, and three of its diastereomers were prepared by a versatile, convergent strategy from three key segments (see scheme). Comparison of the synthetic compounds with natural material established conclusively that FR252921 has the configuration 12 S ,13 R ,18 R.
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