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An Artificial Base Pair, Mediated by Hydrogen Bonding and Metal‐Ion Binding
Author(s) -
Polonius FabianAlexander,
Müller Jens
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700315
Subject(s) - nucleobase , oligonucleotide , base pair , hydrogen bond , chemistry , crystallography , metal , thymine , base (topology) , stereochemistry , combinatorial chemistry , dna , molecule , biochemistry , mathematics , organic chemistry , mathematical analysis
Silver service : Addition of silver(I) to an oligonucleotide comprising 1‐deazaadenine and thymine nucleobases leads to the formation of a Hoogsteen‐type double helix with specific binding of one metal ion per base pair (see scheme). Each base pair is mediated by one hydrogen bond and by two coordination bonds.
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