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Charge‐Monitoring Laser‐Induced Acoustic Desorption Mass Spectrometry for Cell and Microparticle Mass Distribution Measurement
Author(s) -
Peng WenPing,
Lin HuanChang,
Lin HsinHung,
Chu Minglee,
Yu Alice L.,
Chang HuanCheng,
Chen ChungHsuan
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700309
Subject(s) - microparticle , mass spectrometry , laser , analytical chemistry (journal) , chemistry , measure (data warehouse) , charge (physics) , desorption , materials science , chromatography , optics , physics , adsorption , quantum mechanics , database , computer science , organic chemistry
Mass exodus : A mass spectrometer for the rapid measurement of mass distributions of cells and microparticles is described. A discharge process is used to provide cells with thousands of charges so that direct charge measurement can be achieved. This device was used to measure microparticles with masses as high as 10 15 Da and to distinguish cancer cells from normal cells.