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Host–Guest Binding Constants Can Be Estimated Directly from the Product Distributions of Dynamic Combinatorial Libraries
Author(s) -
Ludlow R. Frederick,
Liu Jingyuan,
Li Hongxia,
Roberts Sarah L.,
Sanders Jeremy K. M.,
Otto Sijbren
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200700292
Subject(s) - measure (data warehouse) , product (mathematics) , reading (process) , host (biology) , affinities , constant (computer programming) , binding affinities , computer science , mathematics , chemistry , stereochemistry , data mining , biology , programming language , geometry , genetics , linguistics , philosophy , receptor
Reading a library without opening the books : It is possible to obtain most host–guest binding affinities, even in libraries of more than 30 components, directly from library product distributions by using a numerical data‐fitting procedure. With this technique, it is not necessary to isolate any individual library members or measure binding constants.